Impact of log(Kow) Value on the Extraction of Antibiotics from River Sediments with Pressurized Liquid Extraction

The quantification of antibiotics (ABs) in sediments is an analytical challenge, but at the same time, it indispensable to understand fate ABs aquatic systems such as rivers. aim this study was develop a comprehensive method determine 19 classified macrolides, sulfonamides, fluoroquinolones, tetracyclines, clindamycin and trimethoprim river sediments, using combination pressurized liquid extraction solid phase with separation detection chromatography coupled mass spectrometry. Our results showed that physical-chemical properties (e.g., log(Kow) value) analytes affected efficiency. Therefore, we propose order based on their values instead traditional classification (macrolides, sulfonamides etc.) select suitable solvent. below zero (mainly fluoroquinolones tetracyclines) were difficult extract all tested protocols compared larger than zero. After comparing different for from concluded recoveries range 0.8 64.8% could be achieved value mixture acetonitrile 50 mM phosphoric acid (50/50, v/v) two cycles 100 °C.